A "SMART" Design for Building Individualized Treatment Sequences

A "SMART" design for building individualized treatment sequences.

Interventions often involve a sequence of decisions. For example, clinicians frequently adapt the intervention to an individual's outcomes. Altering the intensity and type of intervention over time is crucial for many reasons, such as to obtain improvement if the individual is not responding or to reduce costs and burden when intensive treatment is no longer necessary. Adaptive interventions ut...

Using Sequential, Multiple Assignment, Randomized Trial (SMART) Designs to Build Individualized Treatment Sequences

Robust Control Design of a Smart Building Structure

This paper presents an application of a design method of robust H∞ optimal control to a structural control system. A dynamic model for a building structure under earthquake and wind excitations is considered. Structured uncertainties are introduced to reflect errors between the model and the reality. To obtain the best possible performance in the face of uncertainties, robust H∞ optimal control...

investigating the feasibility of a proposed model for geometric design of deployable arch structures

deployable scissor type structures are composed of the so-called scissor-like elements (sles), which are connected to each other at an intermediate point through a pivotal connection and allow them to be folded into a compact bundle for storage or transport. several sles are connected to each other in order to form units with regular polygonal plan views. the sides and radii of the polygons are...

The Mayo Clinic Biobank: a building block for individualized medicine.

OBJECTIVE To report the design and implementation of the first 3 years of enrollment of the Mayo Clinic Biobank. PATIENTS AND METHODS Preparations for this biobank began with a 4-day Deliberative Community Engagement with local residents to obtain community input into the design and governance of the biobank. Recruitment, which began in April 2009, is ongoing, with a target goal of 50,000. An...